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KMID : 0359320030430040551
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Korean Journal of Veterinary Research
2003 Volume.43 No. 4 p.551 ~ p.554
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Expression and localization of endothelial and inducible nitric oxide synthase in bovine uterus
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Lee, Yongduk/이용덕
Kim, Seungjoon/Moon, Changjong/Shin, Taekyun/김승준/문창종/신태균
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Abstract
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Nitric oxide synthase (NOS) has been reported in uterus. We examined the expression of the NOS isoforms, constitutive endothelial (eNOS) and inducible NOS (iNOS), in bovine uterus by immunohistochernistry. eNOS immunoreactivity was localized predominantly to the endothelial cells that line uterine microvessels and to endometrial glandular epithelial cells, but was barely detectable in endometrial stromal cells. iNOS immunostaining was detected in glandular epithelial and stromal cells in the endometrium and in the endothelial cells of myometrial blood vessels. These findings suggest that both eNOS and iNOS may play important roles in the physiology of the uterus, possibly by generating NO.
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